There are multiple differences between exFAT, FAT32, NTFS and APFS file systems. To choose the best file system, you have to know how is your USB drive going to be used. Each of the file systems has its advantages and disadvantages.
Differences between NTFS, exFAT, FAT32 and APFS:
- NTFS - is a default file system for Windows. It supports read/write on Windows devices, but generally only read on Mac devices. Other advantages are encryption, enhanced reliability and data integrity.
- exFAT - offers wider cross-platform read/write compatibility, generally works on Windows, Mac and Linux. Doesn't support journaling and doesn't have built-in encryption, but it can be managed by thrid-party apps.
- FAT32 - older file system, compatible with many devices, but has a 4 GB limit for a maximum individual file size. Doesn't have journaling and build-in encryption.
- APFS - is developed by Apple for macOS and iOS. It offers features like advanced encryption and improved reliability. Doesn't natively support Windows and may be incompatible with older macOS versions.